Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
Identifieur interne : 000D60 ( Main/Exploration ); précédent : 000D59; suivant : 000D61Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
Auteurs : Eike R. Hrincius [États-Unis] ; Swantje Liedmann [Allemagne] ; David Finkelstein [États-Unis] ; Peter Vogel [États-Unis] ; Shane Gansebom [États-Unis] ; Amali E. Samarasinghe [États-Unis] ; Dahui You [États-Unis] ; Stephania A. Cormier [États-Unis] ; Jonathan A. Mccullers [États-Unis]Source :
- Cell reports [ 2211-1247 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Cellules HEK293, Cellules rénales canines Madin-Darby, Chiens, Glycosylation, Grippe humaine (immunologie), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Immunité innée (immunologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (métabolisme), Infections à Orthomyxoviridae (virologie), Lésion pulmonaire aigüe (immunologie), Lésion pulmonaire aigüe (métabolisme), Lésion pulmonaire aigüe (virologie), Souris, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Stress du réticulum endoplasmique (immunologie), Transduction du signal.
- MESH :
- immunologie : Grippe humaine, Immunité innée, Infections à Orthomyxoviridae, Lésion pulmonaire aigüe, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Stress du réticulum endoplasmique.
- métabolisme : Grippe humaine, Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- virologie : Grippe humaine, Infections à Orthomyxoviridae, Lésion pulmonaire aigüe.
- Animaux, Cellules HEK293, Cellules rénales canines Madin-Darby, Chiens, Glycosylation, Humains, Souris, Transduction du signal.
English descriptors
- KwdEn :
- Acute Lung Injury (immunology), Acute Lung Injury (metabolism), Acute Lung Injury (virology), Animals, Dogs, Endoplasmic Reticulum Stress (immunology), Glycosylation, HEK293 Cells, Humans, Immunity, Innate (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Influenza, Human (metabolism), Influenza, Human (virology), Madin Darby Canine Kidney Cells, Mice, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (virology), Signal Transduction.
- MESH :
- immunology : Acute Lung Injury, Endoplasmic Reticulum Stress, Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Orthomyxoviridae Infections.
- metabolism : Acute Lung Injury, Influenza, Human, Orthomyxoviridae Infections.
- virology : Acute Lung Injury, Influenza, Human, Orthomyxoviridae Infections.
- Animals, Dogs, Glycosylation, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Mice, Signal Transduction.
Abstract
Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate "non-self" at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections.
DOI: 10.1016/j.celrep.2015.05.012
PubMed: 26051937
Affiliations:
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Hrincius</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Liedmann, Swantje" sort="Liedmann, Swantje" uniqKey="Liedmann S" first="Swantje" last="Liedmann">Swantje Liedmann</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Finkelstein, David" sort="Finkelstein, David" uniqKey="Finkelstein D" first="David" last="Finkelstein">David Finkelstein</name><affiliation wicri:level="2"><nlm:affiliation>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Vogel, Peter" sort="Vogel, Peter" uniqKey="Vogel P" first="Peter" last="Vogel">Peter Vogel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Veterinary Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Gansebom, Shane" sort="Gansebom, Shane" uniqKey="Gansebom S" first="Shane" last="Gansebom">Shane Gansebom</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E" last="Samarasinghe">Amali E. Samarasinghe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="You, Dahui" sort="You, Dahui" uniqKey="You D" first="Dahui" last="You">Dahui You</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Cormier, Stephania A" sort="Cormier, Stephania A" uniqKey="Cormier S" first="Stephania A" last="Cormier">Stephania A. Cormier</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address: jmccullers@uthsc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (immunology)</term><term>Acute Lung Injury (metabolism)</term><term>Acute Lung Injury (virology)</term><term>Animals</term><term>Dogs</term><term>Endoplasmic Reticulum Stress (immunology)</term><term>Glycosylation</term><term>HEK293 Cells</term><term>Humans</term><term>Immunity, Innate (immunology)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (virology)</term><term>Madin Darby Canine Kidney Cells</term><term>Mice</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Orthomyxoviridae Infections (virology)</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules HEK293</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Glycosylation</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (métabolisme)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Immunité innée (immunologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (métabolisme)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Lésion pulmonaire aigüe (immunologie)</term><term>Lésion pulmonaire aigüe (métabolisme)</term><term>Lésion pulmonaire aigüe (virologie)</term><term>Souris</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Stress du réticulum endoplasmique (immunologie)</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Immunité innée</term><term>Infections à Orthomyxoviridae</term><term>Lésion pulmonaire aigüe</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Stress du réticulum endoplasmique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acute Lung Injury</term><term>Endoplasmic Reticulum Stress</term><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Lung Injury</term><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Lésion pulmonaire aigüe</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Lésion pulmonaire aigüe</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Acute Lung Injury</term><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Glycosylation</term><term>HEK293 Cells</term><term>Humans</term><term>Madin Darby Canine Kidney Cells</term><term>Mice</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HEK293</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Glycosylation</term><term>Humains</term><term>Souris</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resulting from recognition of non-adapted viruses is utilized to discriminate "non-self" at the level of protein processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. </div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li><li>Tennessee</li></region><settlement><li>Münster</li></settlement></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Hrincius, Eike R" sort="Hrincius, Eike R" uniqKey="Hrincius E" first="Eike R" last="Hrincius">Eike R. Hrincius</name></region><name sortKey="Cormier, Stephania A" sort="Cormier, Stephania A" uniqKey="Cormier S" first="Stephania A" last="Cormier">Stephania A. Cormier</name><name sortKey="Finkelstein, David" sort="Finkelstein, David" uniqKey="Finkelstein D" first="David" last="Finkelstein">David Finkelstein</name><name sortKey="Gansebom, Shane" sort="Gansebom, Shane" uniqKey="Gansebom S" first="Shane" last="Gansebom">Shane Gansebom</name><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name><name sortKey="Samarasinghe, Amali E" sort="Samarasinghe, Amali E" uniqKey="Samarasinghe A" first="Amali E" last="Samarasinghe">Amali E. Samarasinghe</name><name sortKey="Vogel, Peter" sort="Vogel, Peter" uniqKey="Vogel P" first="Peter" last="Vogel">Peter Vogel</name><name sortKey="You, Dahui" sort="You, Dahui" uniqKey="You D" first="Dahui" last="You">Dahui You</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Liedmann, Swantje" sort="Liedmann, Swantje" uniqKey="Liedmann S" first="Swantje" last="Liedmann">Swantje Liedmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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